Spontaneous inactivating p53 mutations and the “selfish cell”
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منابع مشابه
Spontaneous inactivating p53 mutations and the “selfish cell”
reported in Aging that murine embryo fibroblasts (MEFs) undergo p53 mutations and subsequent immortalizations in culture. This " release from cell cycle arrest " occurs in murine fibroblasts with a humanized or murine WT p53 [1]. The authors also noted that the cultured cells had frequently sustained a mutation matching a human tumor p53 mutation. Jang, et al. also reported spontaneous " immort...
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ژورنال
عنوان ژورنال: Aging
سال: 2011
ISSN: 1945-4589
DOI: 10.18632/aging.100294